Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?
Identifieur interne : 002D28 ( Main/Exploration ); précédent : 002D27; suivant : 002D29Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?
Auteurs : RBID : pubmed:16253136English descriptors
- KwdEn :
- Animals, Anoxia (complications), Anoxia (pathology), Anoxia (surgery), Cell Survival, Hypertension, Pulmonary (pathology), Hypertension, Pulmonary (surgery), Infusions, Parenteral, Male, Mesenchymal Stem Cell Transplantation (methods), Mesenchymal Stromal Cells (pathology), Pulmonary Artery (pathology), Pulmonary Artery (surgery), Rats, Rats, Wistar, Treatment Outcome.
- MESH :
- complications : Anoxia.
- methods : Mesenchymal Stem Cell Transplantation.
- pathology : Anoxia, Hypertension, Pulmonary, Mesenchymal Stromal Cells, Pulmonary Artery.
- surgery : Anoxia, Hypertension, Pulmonary, Pulmonary Artery.
- Animals, Cell Survival, Infusions, Parenteral, Male, Rats, Rats, Wistar, Treatment Outcome.
Abstract
Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-derived mesenchymal stem cells (MSCs) into non-irradiated rats.
DOI: 10.1186/1465-9921-6-125
PubMed: 16253136
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?</title><author><name sortKey="Rochefort, Gael Y" uniqKey="Rochefort G">Gaël Y Rochefort</name><affiliation wicri:level="3"><nlm:affiliation>LABPART-EA3852, IFR135, Université François Rabelais, Faculté de Médecine, 10 Boulevard Tonnellé, 370032 TOURS, France. gael.rochefort@med.univ-tours.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LABPART-EA3852, IFR135, Université François Rabelais, Faculté de Médecine, 10 Boulevard Tonnellé, 370032 TOURS</wicri:regionArea><placeName><region type="region" nuts="2">Région Centre</region><settlement type="city">TOURS</settlement></placeName></affiliation></author><author><name sortKey="Vaudin, Pascal" uniqKey="Vaudin P">Pascal Vaudin</name></author><author><name sortKey="Bonnet, Nicolas" uniqKey="Bonnet N">Nicolas Bonnet</name></author><author><name sortKey="Pages, Jean Christophe" uniqKey="Pages J">Jean-Christophe Pages</name></author><author><name sortKey="Domenech, Jorge" uniqKey="Domenech J">Jorge Domenech</name></author><author><name sortKey="Charbord, Pierre" uniqKey="Charbord P">Pierre Charbord</name></author><author><name sortKey="Eder, Veronique" uniqKey="Eder V">Véronique Eder</name></author></titleStmt><publicationStmt><date when="2005">2005</date><idno type="doi">10.1186/1465-9921-6-125</idno><idno type="RBID">pubmed:16253136</idno><idno type="pmid">16253136</idno><idno type="wicri:Area/Main/Corpus">002D48</idno><idno type="wicri:Area/Main/Curation">002D48</idno><idno type="wicri:Area/Main/Exploration">002D28</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anoxia (complications)</term><term>Anoxia (pathology)</term><term>Anoxia (surgery)</term><term>Cell Survival</term><term>Hypertension, Pulmonary (pathology)</term><term>Hypertension, Pulmonary (surgery)</term><term>Infusions, Parenteral</term><term>Male</term><term>Mesenchymal Stem Cell Transplantation (methods)</term><term>Mesenchymal Stromal Cells (pathology)</term><term>Pulmonary Artery (pathology)</term><term>Pulmonary Artery (surgery)</term><term>Rats</term><term>Rats, Wistar</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anoxia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mesenchymal Stem Cell Transplantation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Anoxia</term><term>Hypertension, Pulmonary</term><term>Mesenchymal Stromal Cells</term><term>Pulmonary Artery</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Anoxia</term><term>Hypertension, Pulmonary</term><term>Pulmonary Artery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Survival</term><term>Infusions, Parenteral</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-derived mesenchymal stem cells (MSCs) into non-irradiated rats.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16253136</PMID><DateCreated><Year>2005</Year><Month>11</Month><Day>28</Day></DateCreated><DateCompleted><Year>2006</Year><Month>03</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>09</Month><Day>05</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1465-993X</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2005</Year></PubDate></JournalIssue><Title>Respiratory research</Title><ISOAbbreviation>Respir. Res.</ISOAbbreviation></Journal><ArticleTitle>Influence of hypoxia on the domiciliation of mesenchymal stem cells after infusion into rats: possibilities of targeting pulmonary artery remodeling via cells therapies?</ArticleTitle><Pagination><MedlinePgn>125</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Bone marrow (BM) cells are promising tools for vascular therapies. Here, we focused on the possibility of targeting the hypoxia-induced pulmonary artery hypertension remodeling with systemic delivery of BM-derived mesenchymal stem cells (MSCs) into non-irradiated rats.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Six-week-old Wistar rats were exposed to 3-week chronic hypoxia leading to pulmonary artery wall remodeling. Domiciliation of adhesive BM-derived CD45- CD73+ CD90+ MSCs was first studied after a single intravenous infusion of Indium-111-labeled MSCs followed by whole body scintigraphies and autoradiographies of different harvested organs. In a second set of experiments, enhanced-GFP labeling allowed to observe distribution at later times using sequential infusions during the 3-week hypoxia exposure.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A 30% pulmonary retention was observed by scintigraphies and no differences were observed in the global repartition between hypoxic and control groups. Intrapulmonary radioactivity repartition was homogenous in both groups, as shown by autoradiographies. BM-derived GFP-labeled MSCs were observed with a global repartition in liver, in spleen, in lung parenchyma and rarely in the adventitial layer of remodeled vessels. Furthermore this global repartition was not modified by hypoxia. Interestingly, these cells displayed in vivo bone marrow homing, proving a preservation of their viability and function. Bone marrow homing of GFP-labeled MSCs was increased in the hypoxic group.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Adhesive BM-derived CD45- CD73+ CD90+ MSCs are not integrated in the pulmonary arteries remodeled media after repeated intravenous infusions in contrast to previously described in systemic vascular remodeling or with endothelial progenitor cells infusions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rochefort</LastName><ForeName>Gaël Y</ForeName><Initials>GY</Initials><Affiliation>LABPART-EA3852, IFR135, Université François Rabelais, Faculté de Médecine, 10 Boulevard Tonnellé, 370032 TOURS, France. gael.rochefort@med.univ-tours.fr</Affiliation></Author><Author ValidYN="Y"><LastName>Vaudin</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Pages</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Domenech</LastName><ForeName>Jorge</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Charbord</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Eder</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2005</Year><Month>10</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Respir Res</MedlineTA><NlmUniqueID>101090633</NlmUniqueID><ISSNLinking>1465-9921</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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Parenteral</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mesenchymal Stem Cell Transplantation</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mesenchymal Stromal Cells</DescriptorName><QualifierName MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pulmonary Artery</DescriptorName><QualifierName MajorTopicYN="Y">pathology</QualifierName><QualifierName MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><OtherID 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